Last pieces of 1 World Trade Center are rising

FILE - One World Trade Center rises above the lower Manhattan skyline, April 13, 2013 in New York. It is already New York?s tallest building. But when the last pieces of its spire go up to the roof Monday, April 28, the 104-floor skyscraper will be one step away from becoming the highest in the Western Hemisphere. (AP Photo/Mark Lennihan, File)

FILE - One World Trade Center rises above the lower Manhattan skyline, April 13, 2013 in New York. It is already New York?s tallest building. But when the last pieces of its spire go up to the roof Monday, April 28, the 104-floor skyscraper will be one step away from becoming the highest in the Western Hemisphere. (AP Photo/Mark Lennihan, File)

FILE - In this file photo of April 26, 2013, from Bayonne, N.J., One World Trade Center rises behind the Statue of Liberty in New York. It is already New York?s tallest building. But when the last pieces of its spire go up to the roof Monday, April 28, the 104-floor skyscraper will be one step away from becoming the highest in the Western Hemisphere. (AP Photo/Mark Lennihan, File)

FILE - In this file photo of April 18, 2013, construction cranes work on assembling the rising spire on top of One World Trade Center in New York. It is already New York?s tallest building. But when the last pieces of its spire go up to the roof Monday, April 28, the 104-floor skyscraper will be one step away from becoming the highest in the Western Hemisphere. (AP Photo/Mark Lennihan, File)

NEW YORK (AP) ? One World Trade Center already is New York's tallest building.

And when the last pieces of its spire rise to the roof ? weather permitting ? the 104-floor skyscraper that replaces the fallen twin towers will be just feet from becoming the highest in the Western Hemisphere.

The Port Authority of New York and New Jersey says the spire pieces plus a steel beacon will then be lifted at a later date from the rooftop to cap the building at 1,776 feet.

Installation of the 800-ton, 408-foot spire began in December, after 18 pieces were shipped from Canada and New Jersey.

The spire will serve as a world-class broadcast antenna.

With the beacon at its peak to ward off aircraft, the spire will provide public transmission services for television and radio broadcast channels that were destroyed on Sept. 11, 2001, along with the trade center towers.

Overlooking the Statue of Liberty and Ellis Island, the high-rise is scheduled to open for business in 2014.

The tower is at the northwest corner of the site, which is well on its way to reconstruction with the 72-story 4 World Trade Center and other buildings.

Monday's celebration of the reconstructed trade center comes days after a grisly reminder of the terror attack that took nearly 3,000 lives: the discovery of a rusted piece of airplane landing gear wedged between a nearby mosque and an apartment building ? believed to be from one of the hijacked planes that ravaged lower Manhattan.

As officials prepared to erect the spire, the office of the city's chief medical examiner was working in the hidden alley where debris may still contain human remains.

The new tower's crowning spire is a joint venture between the ADF Group Inc. engineering firm in Terrebonne, Quebec, and New York-based DCM Erectors Inc., a steel contractor.

The world's tallest building, topping 2,700 feet, is in Dubai.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-29-World%20Trade%20Center%20Spire/id-ed7a141aa8a649799040b123e73e506f

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Scientists create novel approach to find RNAs involved in long-term memory storage

Scientists create novel approach to find RNAs involved in long-term memory storage

Friday, April 26, 2013

Despite decades of research, relatively little is known about the identity of RNA molecules that are transported as part of the molecular process underpinning learning and memory.

Now, working together, scientists from the Florida campus of The Scripps Research Institute (TSRI), Columbia University and the University of Florida, Gainesville, have developed a novel strategy for isolating and characterizing a substantial number of RNAs transported from the cell-body of neuron (nerve cell) to the synapse, the small gap separating neurons that enables cell to cell communication.

Using this new method, the scientists were able to identify nearly 6,000 transcripts (RNA sequences) from the genome of Aplysia, a sea slug widely used in scientific investigation.

The scientists' target is known as the synaptic transcriptome?roughly the complete set of RNA molecules transported from the neuronal cell body to the synapse.

In the study, published recently in the journal Proceedings of the National Academy of Sciences, the scientists focused on the RNA transport complexes that interact with the molecular motor kinesin; kinesin proteins move along filaments known as microtubules in the cell and carry various gene products during the early stage of memory storage.

While neurons use active transport mechanisms such as kinesin to deliver RNA cargos to synapses, once they arrive at their synaptic destination that service stops and is taken over by other, more localized mechanisms?in much the same way that a traveler's bags gets handed off to the hotel doorman once the taxi has dropped them at the entrance.

The scientists identified thousands of these unique sequences of both coding and noncoding RNAs. As it turned out, several of these RNAs play key roles in the maintenance of synaptic function and growth.

The scientists also uncovered several antisense RNAs (paired duplicates that can inhibit gene expression), although what their function at the synapse might be remains unknown.

"Our analyses suggest that the transported RNAs are surprisingly diverse," said Sathya Puthanveettil, a TSRI assistant professor who designed the study. "It also brings up an important question of why so many different RNAs are transported to synapses. One reason may be that they are stored there to be used later to help maintain long-term memories."

The team's new approach offers the advantage of avoiding the dissection of neuronal processes to identify synaptically localized RNAs by focusing on transport complexes instead, Puthanveettil said. This new approach should help in better understanding changes in localized RNAs and their role in local translation as molecular substrates, not only in memory storage, but also in a variety of other physiological conditions, including development.

"New protein synthesis is a prerequisite for maintaining long term memory," he said, "but you don't need this kind of transport forever, so it raises many questions that we want to answer. What molecules need to be synthesized to maintain memory? How long is this collection of RNAs stored? What localized mechanisms come into play for memory maintenance?"

###

In addition to Puthanveettil, who was the first author of the study, authors of "A Strategy to Capture and Characterize the Synaptic Transcriptome," include Igor Antonov, Sergey Kalchikov, Priyamvada Rajasethupathy, Yun-Beom Choi, Maxime Kinet, Irina Morozova, James J. Russo, and Jingyue Ju of Columbia University; Kevin A. Karl of the Howard Hughes Medical Institute; and Eric R. Kandel of Columbia University, the Howard Hughes Medical Institute and the Kavli Institute for Brain Science; and Andrea B. Kohn, Mathew Citarella, Fahong Yu and Leonid L. Moroz of the University of Florida, Gainesville. For more information, see http://www.pnas.org/content/early/2013/04/10/1304422110.long

Scripps Research Institute: http://www.scripps.edu

Thanks to Scripps Research Institute for this article.

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Source: http://www.labspaces.net/127967/Scientists_create_novel_approach_to_find_RNAs_involved_in_long_term_memory_storage

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The Logos of Terrorist Organizations Predictably Love Using Guns

In a book called Branding Terror, Francesco Trivini Bellini and former United Nations counter-terrorism analyst Artur Beifuss compiled the logos and brand identities of terrorist organizations "from al-Qaeda to the Real IRA" and analyzed them as they would any logo. It's fascinating to approach the identity of the terrorists from a graphic design perspective. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/bqZg1pIjS0Y/the-logos-of-terrorist-organizations-predictably-love-using-guns

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Keystone XL opponents brace for protests in Neb.

GRAND ISLAND, Neb. (AP) ? Opponents of a massive Canada-to-Texas oil pipeline converged on a snowy Nebraska town Thursday for a critical hearing on the project, but they already were preparing possible acts of civil disobedience should President Barack Obama ultimately approve it.

Despite a spring storm that brought sleet and snow to Nebraska, the U.S. State Department hearing in Grand Island drew more than 1,000 people from the around state, as well as activists from outside the region who consider Nebraska a key battleground over the Keystone XL pipeline.

As they waited in line for an opportunity to speak, many activists outlined plans for civil disobedience and state-court lawsuits designed to keep the project from moving forward. Project foes have promised to block workers, lie down in front of equipment and do whatever it takes to stop the pipeline from connecting Canada's tar sands region to Texas refineries.

Abbie Kleinschmidt, 54, of York, said she was prepared to stand in front of TransCanada's bulldozers in Nebraska if the pipeline is approved. The fifth-generation farmer said she fears that the half-mile of pipeline that could run through her corn and soybean farm would contaminate the groundwater that has sustained her family for generations.

"I hope it doesn't come to that," she said. "But it's our job, our duty, to take care of this land."

Terry Frisch, a northern Nebraska who owns land on the Ogallala Aquifer, has fought the project for four years. He said he has grown increasingly frustrated that the project, which he views as a threat to the state's groundwater supply. Frisch said some landowners are so angry in the desolate ranching country are so angry that some have discussed fighting back if they're moved by force.

"I'm 65 years old, and I've already lived longer than I thought I was going to," Frisch said. "I'm not going to ask my kids. But me? I'm not afraid to stand in front of a bulldozer."

Opponents are also looking to challenge the project in ways beyond physical protests, said Jane Kleeb, executive director of the anti-pipeline group Bold Nebraska. If the project wins approval, she said, many land owners are planning to challenge the company's eminent domain authority through the courts. She stressed that any protests to block the pipeline will be peaceful.

Even if Obama approves the $7.6 billion line, opponents said before the eight-hour hearing that they wouldn't give in.

"In Nebraska, you don't just take land," said Bill Dunavan, whose farmland sits in the pipeline's path. He and his wife are plaintiffs in a lawsuit that is challenging a state law that allowed for the project to move ahead.

On the national front, activists are gathering signatures from Nebraska residents and others who are willing to risk arrest if the president allows the pipeline to proceed. Becky Bond, a San Francisco-based policy for CREDO Action, a cellphone company and progressive advocacy group, said 830 Nebraska residents have signed so far out of 59,000 people nationwide. In Nebraska, she said, the effort would likely include blocking construction crews.

Project supporters argue that opponents are well-intended but misguided.

"There is no alternative to pipelines. There is no safer way," said Brigham McCown, a former administrator for the federal Pipeline and Hazardous Materials Safety Administration under the Bush administration. "I've looked at this project, and . . . I wish every pipeline in this country were built to this project's specifications."

After months of quiet, a State Department report has cleared the way for a final decision on the plan by Calgary-based TransCanada to transport oil extracted from Alberta tar sands more than 1,700 miles to refineries on the Gulf Coast.

Opponents are now focused on the new secretary of state, John Kerry, who will make a recommendation to President Barack Obama on whether to green-light the project.

Activists said they remain hopeful Obama will reject the pipeline due to environmental concerns ranging from possible spills to the effects of the project on global warming. The pipeline would carry an estimated 800,000 barrels of oil a day.

Nebraska Gov. Dave Heineman opposed the initial route but supported it after the route was changed to veer away from an area that state officials designated as the ecologically sensitive Sandhills region, which overlies the sprawling Ogallala Aquifer. Heineman said he's satisfied the state listened to landowners' concerns, noting a 2,000-page review by the state Department of Environmental Quality that concluded the project would have a minimal environmental impact.

TransCanada spokesman Shawn Howard also said the company has listened to the concerns of Nebraska residents during a series of state environmental hearings. The company also submitted to four federal environmental reviews and nearly a dozen state and local ones, he said.

Source: http://news.yahoo.com/keystone-xl-opponents-brace-protests-neb-184608858.html

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Hispanics, Well ... Turn Out to Be Democrats (talking-points-memo)

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Vocal cord disorder often mistaken for asthma in elite athletes

Apr. 12, 2013 ? Athletes with a vocal cord disorder that restricts breathing are more likely to be misdiagnosed and inappropriately treated for exercise-induced asthma, according to research presented today at the Triological Society's 116th Annual Meeting.

Researchers at The Ohio State University Wexner Medical Center also examined interventions ranging from biofeedback to botox injections to help manage the condition -- called paradoxical vocal fold motion disorder (PVFMD) -- and found that vocal cord "retraining" therapy was effective at reducing or resolving breathing symptoms, allowing many athletes to stop using previously prescribed corticosteroid asthma inhalers.

The retrospective study examined 46 division one collegiate athletes, marathon and triathlon runners who were newly diagnosed with PVFMD, a condition brought on by stress, anxiety or increased exertion which causes the vocal cords to constrict and obstruct breathing. An estimated five percent of athletes have PVFMD, which can severely impact performance.

"There isn't a lot in the literature about PVFMD in elite athletes, and our study shows that because of their high level of conditioning they may be more difficult to diagnose and treat than non-athletes." said Brad deSilva, MD, the study's lead investigator and residency program director for the Department of Otolaryngology-Head and Neck Surgery at Ohio State's Wexner Medical Center.

For example, only 30 percent of the study group reported consistently experiencing PVFMD symptoms like coughing during exercise. However, in post-exertion testing using a flexible fiberoptic laryngoscope (FFL), researchers ultimately verified PVFMD diagnosis in all but six of the athletes. Additionally, in comparison to a control cohort of non-athletes with PVFMD, athletes were less likely to present with a history of reflux, laryngeal edema or psychiatric diagnosis.

The study presenters noted that the addition of the exercise trigger during FFL improved the researcher's ability to detect PVFMD, and that clinicians may want to strongly consider FFL examination when dealing with an elite athlete patient with breathing issues, particularly because the respiratory sounds of PVFMD may be confused with asthma.

"PVFMD symptoms can often mimic asthma, and as many as 40 percent of people with asthma also have PVFMD -- so it's typical for an athlete to get the asthma diagnosed correctly, but not the vocal cord dysfunction," said Anna Marcinow, MD, co-author of the study and a senior resident in the otolaryngology program at Ohio State's College of Medicine. "Nearly a third of our study athletes had been previously prescribed an inhaler for exercise-induced asthma -- but many reported that the inhalers weren't helping. A minimal response to bronchodilators should also point toward a PVFMD diagnosis."

After FFL review, 45 of the 46 athletes in the study were prescribed laryngeal control therapy (LCT), a method in which athletes learn how to relax the vocal cords and retrain the way they breathe. Thirty-six athletes attended at least one LCT session and 25 (69 percent) reported improvement of symptoms. Patients who attended two or more sessions were more likely to experience symptom improvement.

Biofeedback, practice observed therapy and thyroarytenoid muscle botulinum toxin injection were utilized in patients that did not respond to LCT.

"Because PVFMD can have both physical and emotional impacts, using tactics that help athletes gain a sense of control over their breathing can be really effective," said Marcinow. "Athletes may also need additional alternative forms of therapy such as biofeedback or intervention from a sports psychologist."

The researchers also noted that while PVFMD is first often seen in athletes who have recently intensified activity and training, it can also occur in non-athletes who are adopting a more rigorous exercise program.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/J4oBFWbn2_c/130412192400.htm

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Comedian Jonathan Winters dies at 87

Getty Images file

Jonathan Winters at the TV Land Awards in 2008.

By Anna Chan, TODAY

Jonathan Winters, the actor and comedian who gained fame with his roles in "It's a Mad, Mad, Mad, Mad World," "The Loved One" and "Mork and Mindy" has died. He was 87.

Winters' agent told NBC News that the actor died of natural causes Thursday night at his home in Montecito, Calif. He was surrounded by family and friends.

Winters was born in Dayton, Ohio, on Nov. 11, 1925. His career kicked off when his wife, Eileen, encouraged him to enter a talent contest, which he won. That performance led to a DJ job at WING in Dayton in 1946, and he eventually moved to New York and became a performer at Manhattan's Blue Angel nightclub.?

Winters became known for his numerous classic comedy characters and routines, including sharp-tongued Maude Frickert, whom Winters said he based on a large humorous but bedridden relative. ?I decided having seen a lot of older people that many of them even today are shelved,? Winters told the Archive of American Television. ?I decided to get a hip old lady.? Johnny Carson was inspired by Frickert to create his own version, Aunt Blabby.

His improvisational comedy inspired a generation. In a classic 1964 clip from "The Jack Paar Program," host Paar hands Winters a stick and the comic launches into four minutes of off-the-cuff prop humor, switching from an all-American fisherman to an Austrian violinist to a Spanish bullfighter.

Winters worked as an actor in more than 73 movies and television shows, according to IMDb.com, and currently has two projects in post-production: the voice of Papa Smurf in "The Smurfs 2," due to be released in July, and a character named Dayton in "Big Finish," which is scheduled for late next year.?

Everett Collection

From left, Robin Williams, Jonathan Winters and Pam Dawber on 1980s sitcom "Mork & Mindy."

One of his most popular roles was that of Mearth, Mork (Robin Williams) and Mindy's (Pam Dawber) child, who was hatched -- as a fully grown adult -- from an egg Mork laid. The character was introduced during the show's fourth and final season in the hopes of improving the sci-fi comedy's ratings. Winters had previously made a guest appearance on the show in season three as Mindy's uncle Dave.

Winters also voiced multiple commercials. Among his most popular ads were the ones he did for Hefty garbage bags, in which he played a garbageman dressed to the nines in a spiffy white suit.

Comedians took to Twitter Friday morning to remember the comic and his body of work.

The actor is survived by his two children and five grandchildren.

This breaking news story will be updated.

Source: http://todayentertainment.today.com/_news/2013/04/12/17721920-comedian-jonathan-winters-dies-at-87?lite

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Saturday Football Scrimmage Open to Public

Posted on: 1:53 pm, April 5, 2013, by Chris Breece, updated on: 01:56pm, April 5, 2013

The University of Arkansas has announced Saturday?s football practice will be open to the public inside Donald W. Reynolds Razorback Stadium.

The Razorbacks are in the middle of spring practice, with Saturday?s workout the ninth of 15 NCAA-allotted practices during the spring.

Fans attending can park in lots surrounding the stadium, but due to an all-day event in Barnhill Arena parking availability could be scattered. The only entrance into the stadium will be Gate 6 off Razorback Road, which will open at 11 a.m., ?and all fan seating will be on the West side of the stadium.

Practice will start around 11:25 am with the scrimmage starting around 11:45 am.

Arkansas wraps up its spring practices with the Red-White Spring Game on April 20 at 2 p.m. The game will be held inside Donald W. Reynolds Razorback Stadium and is free to attend.

Source: http://5newsonline.com/2013/04/05/saturday-football-scrimmage-open-to-public/

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